Enduring memory impairment in monkeys after ischemic damage to the hippocampus
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چکیده
منابع مشابه
Enduring memory impairment in monkeys after ischemic damage to the hippocampus.
Patient RB became amnesic following an episode of global ischemia that resulted in a bilateral lesion of the CA1 field of the hippocampus. This finding suggested that damage restricted to the hippocampus is sufficient to produce clinically significant memory impairment. To evaluate further the effect of ischemic brain damage on memory, we have developed an animal model of cerebral ischemia in t...
متن کاملMemory impairment in monkeys following lesions limited to the hippocampus.
This study addressed the question of how severe a memory impairment is produced by a lesion limited to the hippocampus. Monkeys with circumscribed hippocampal lesions were tested on the delayed-nonmatching-to-sample task, a test of recognition memory that is sensitive to amnesia in humans. Monkeys were given no preoperative training and were given no postoperative experience prior to training o...
متن کاملThree cases of enduring memory impairment after bilateral damage limited to the hippocampal formation.
Patient RB (Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus, S. Zola-Morgan, L. R. Squire, and D. G. Amaral, 1986, J Neurosci 6:2950-2967) was the first reported case of human amnesia in which detailed neuropsychological analyses and detailed postmortem neuropathological analyses demonstrated that dama...
متن کاملImpaired recognition memory in rats after damage to the hippocampus.
Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, th...
متن کاملRelationship between magnitude of damage to the hippocampus and impaired recognition memory in monkeys.
Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Neurosci 2000;20:451-463) found no significant correlation between extent of hip...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1992
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.12-07-02582.1992